The Effect of <i>Junci Medulla</i> Herbal-acupuncture at KI<sub>10</sub> on LPS induced Nephritis in Rats

Ihm, Jee Soon; Cho, Tae Hwan; Yim, Yun Kyoung

doi:2012.29.6.73

J Acupunct Res > Volume 29(6); 2012 > Article

Original Article

Journal of Korean Acupuncture & Moxibustion Society 2012;29(6): 73-83.

Published online December 17, 2012.
DOI: https://doi.org/10.13045/kamms.2012087

The Effect of Junci Medulla Herbal-acupuncture at KI₁₀ on LPS induced Nephritis in Rats

Jee Soon Ihm, Tae Hwan Cho, Yun Kyoung Yim

Dept. of Meridian and Acupoint, College of Oriental Medicine, Daejeon University

*Corresponding author.
Yun Kyoung Yim
Tel: +82-42-280-2610 Email: docwindy@dju.krr

Abstract

Objectives : This study aimed to evaluate the effects of Junci Medulla Herbal-acupuncture(JM-HA) at KI₁₀(Umgok) on nephritis induced by lipopolysaccharide(LPS) in rats.
Methods : Rats with nephritis induced by LPS, were treated with JM-HA at KI₁₀ 3 times a week. The rats in the NP group and the saline group were treated with a needle prick and a saline injection respectively. To evaluate the effects of JM-HA at KI10 on nephritis in rats, WBC, neutrophils in blood, BUN, creatinine, TNF-α in serum, creatinine, total protein in urine and renal MPO were measured.
Results : JM-HA at KI₁₀ significantly inhibited the increase of WBC and neutrophils in blood, BUN, creatinine, TNF-α in serum, and MPO in kidney of LPS-stimulated rats. Conclusion : JM-HA at KI₁₀ has therapeutic effects on nephritis in LPS-stimulated rats. Therefore, it is suggested that JM-HA at KI₁₀ may be a useful therapy in clinical field after further researches.

Keywords: nephritis, herbal-acupuncture, KI₁₀, Junci Medulla, LPS