Introduction
Bell’s palsy is a paralysis or weakness of the muscle on one side of the face due to facial nerve damage. The most common symptoms in patients with Bell’s palsy are facial palsy or asymmetry, which is sometimes accompanied by other symptoms such as otalgia, loss of taste, dry eye discomfort, tinnitus, hearing loss, and excessive tears. Facial palsy or asymmetry has a dramatic effect on a patient’s appearance, psychological wellbeing, and quality of life. Therefore, being able to predict the prognosis of Bell’s palsy in a patient using a particular diagnostic test, is valuable [
1].
While prognostic evaluation is controversial, several tools have been proposed for management of treatment [
2]. Electroneurography (ENoG) and electromyography (EMG) provide relatively accurate prognosis of Bell’s palsy by measuring degeneration of affected nerve fibers [
3–
6].
The heart rate variability (HRV) test which measures the variation in time interval between heart beats has been used for assessing the influence of the autonomic nervous system (ANS) [
7]; changes in ANS have been studied to discern whether they affect the prognosis of Bell’s palsy. In a study by Kim et al [
8], the standard deviation of the R-R intervals (SDNN) was shown to have a significant correlation with mean axonal loss when measured using EMG, indicating its value was a prognostic factor; however, they reported the limitation that SDNN did not correlate with improvement in Bell’s palsy symptoms.
In a study by Park et al [
1], diabetes mellitus, and hypertension showed a correlation with improvement of Bell’s palsy symptoms. Similarly, neutrophil to lymphocyte ratio and platelet to lymphocyte ratio have been reported to correlate with improvement of Bell’s palsy symptoms [
9,
10]. Based on these findings, hematology tests including fasting blood sugar, HbA1c, erythrocyte sedimentation rate (ESR), and white blood cell differential counts were conducted on patients hospitalized for Bell’s palsy.
Several studies have investigated ENoG, EMG, HRV, or hematology tests for Bell’s palsy [
1–
5]. However, it is necessary to determine whether these findings are reasonably consistent because individual studies have reported various characteristics, and there has been no overall study of all these tests. In addition, there are few studies that have investigated whether the tests reflect improvement in severity of the initial symptoms.
Therefore, the aim of this study was to determine whether there were any correlations between ENoG, EMG, the hematology and the HRV test indicators, and improvement and initial severity of Bell’s palsy symptoms.
Discussion
Bell’s palsy is the most common cause of unilateral facial palsy, but its pathologic cause and prognostic evaluation are controversial [
12]. Many studies have reported the prognostic value of ENoG and EMG for Bell’s palsy, and these 2 tests have been actively used in clinical practice [
3–
6]. In a study by Kim et al [
8], the HRV test showed the possibility as a prognostic factor, but it had a limitation in that results were not related to the improvement in Bell’s palsy symptoms. In a study by Park et al [
1], age, season of onset, hypertension, diabetes, fasting blood sugar, and the number of treatments were related to the prognosis of Bell’s palsy.
Nevertheless, these studies are not sufficient to confirm a reasonably consistent conclusion. To provide further information, this study was designed to identify the prognostic values of ENoG, EMG, HRV, and hematology tests in Bell’s palsy prognoses. In addition, any correlation between the initial grade of severity and test results was analyzed to identify whether 1 particular test used was more related to the initial severity, or improvement of Bell’s palsy symptoms.
In this study, degeneration detected by using ENoG and EMG did not show significant correlation with initial symptoms but did show statistically significant negative correlations with improvement of Bell’s palsy (
Table 3). This result indicated that the ENoG and EMG results are related to improvement in symptoms rather than the initial severity of Bell’s palsy. In addition, since there was no significant correlation in degeneration of nasalis nerve using ENoG or in that of the zygomaticus branch nerve using EMG, a comprehensive rather than single reading of ENoG and EMG are required for an accurate prognosis.
The HRV test did not correlate with the initial severity, while several values (RMSSD, SDNN, TP, VLF, HF) showed a correlation with the improvement rate of Bell’s palsy symptoms (
Table 5). Therefore, it appears that the HRV test may be related to improvement of Bell’s palsy rather than to initial severity. In a study by Leal [
13], the sympathetic nerve system (SNS) was reported to be responsible for the “fight or flight” response to threatening situations, and diverse stimuli such as stressors, cytokines, and infection triggered the SNS to release catecholamine, enhance host defenses to eliminate pathogens, and promote healing after tissue injury. This early reaction of the SNS induces functional alterations in the immune system and ultimately allows a smooth recovery in the state of inflammation. However, in situations where there is constant hyperactivity of the PNS, the SNS response decreases, which can adversely affect recovery, suggesting that parasympathetic hyperactivity could decrease the improvement in Bell’s palsy symptoms.
Among the HRV indicators, RMSSD, SDNN, TP, and HF showed a significant negative correlation with improvement of Bell’s palsy symptoms (
Table 5); except for TP, these components increase when the PNS is hyperactive [
14,
15]. Thus, it appears that hyperactivity of the PNS can slow the improvement of Bell’s palsy symptoms by decreasing activity of the SNS when in a state of inflammation.
Conversely, in the aforementioned study by Kim et al [
8], there was no significant correlation between the indicators of the HRV test and improvement of Bell’s palsy symptoms. Nevertheless, the authors defined improvement of paralysis as the difference between HBGS at the 1
st examination and the HBGS in the 2
nd week. This is an insufficient period of time to measure the degree of improvement of paralysis, considering that Wallerian degeneration of nerve axons occurs for about 7 days [
16]. Therefore, to compensate for these limitations, this study was conducted on patients who were followed for at least 2 months so that a clearer conclusion could be obtained.
In this study, HbA1c statistically significantly correlated with normalized HBGS improvement index but not with initial HBGS of severity. This result suggested that HbA1c is related to improvement of symptoms of Bell’s palsy rather than the initial severity. The relationship between HbA1c and improvement rate showed a negative correlation, indicating that hyperglycemia can adversely affect improvement of Bell’s palsy symptoms. Therefore, strict blood sugar management is needed to increase the improvement rate of Bell’s palsy symptoms.
The ESR is associated with systematic illnesses and measures the rate at which erythrocytes settle in the plasma of an anticoagulated blood specimen over a specified period of time (usually 60 minutes) in millimeters (mm)/hour [
17]. There are few reports where ESR tests are used in Bell’s palsy, and the prognostic value for Bell’s palsy for inflammation markers such as neutrophil to lymphocyte ratios and platelet to lymphocyte ratios has been reported [
9,
10]. In this study, ESR was not associated with the initial severity of Bell’s palsy symptoms, but ESR was adversely affected with the improvement of symptoms (
Table 4), which suggests that the more severe the inflammatory reaction, the lower is the improvement; in clinical practice, this should be considered to expedite recovery.
This study was conducted to confirm prognostic values and determine whether the initial HBGS of severity of Bell’s palsy was reflected and drew the following conclusions. Initial severity did not correlate with results from the tests performed, and ENoG, EMG, the HRV test, HbA1c, and ESR significantly negatively correlated with predicting Bell’s palsy symptom improvement. Therefore, while it is reasonable to use these tests as a tool for prognosis, they should not be used to determine symptom severity.
ENOGs and EMG have shown prognostic value for Bell’s palsy in many studies, and the results of this study support this finding. Furthermore, this study determined that the level of inflammation as measured using ESR, hyperglycemia, and parasympathetic hyperactivity have a prognostic value. Therefore, it seems that the use of HRV and hematology tests in addition to the existing electrical tests will be helpful in determining the prognosis of Bell’s palsy.
However, in the course of this study, there were limitations. Firstly, individualized treatments, such as variations in acupuncture treatment and in herbal medicine, reduced the level of control. Secondly, the subjective opinions of researchers were reflected in their use of the HB grading system. Therefore, further study with an improved design should be conducted. In addition, even though acupuncture stimulation modulates the ANS by changing the somatosensory reflex and the flow of extravascular fluid [
17], it appeared that the response to treatment for patients with Bell’s palsy was poor when the PNS was hyperactive. Moreover, it was difficult to evaluate the effect of a single treatment because patients received complex EWCT. Despite these treatments, parasympathetic hyperactivity showed an adverse effect on the improvement of Bell’s palsy symptoms, so it is necessary to investigate the mechanism of the adverse effect of hyperactive PNS on treatments individually used.