A Systematic Review on the Efficacy of Fire Needling for the Treatment of Acne

Article information

Acupunct. 2016;33(2):151-164
1Department of Korean medicine, College of Korean medicine, Woosuk University
2Department of Internal medicine, College of Korean medicine, Woosuk University
3Department of Pediatrics, College of Korean medicine, Woosuk University
*Corresponding author: Junghwasandong 2-5 Jeonju, Jeonbuk, Republic of Korea. 560-833, Tel: +82-63-220-8608, E-mail: mackayj@naver.com
Received 2016 May 20; Revised 2016 May 22; Accepted 2016 May 23.

Abstract

Objectives:

The purpose of this study is to review clinical studies about the efficacy of fire needling for the treatment of acne vulgaris.

Methods and Results:

In this review, Oasis, NDSL, CNKI, PubMed, Cochrane, J STAGE and CINII were used as the main databases for searching for medical journals, using the keywords “acne and fire needling”, “acne and fire needle”, “acne and fire acupuncture”, and “acne and red hot needle”, The initial search range included only randomized controlled trials (RCTs), and papers not matching inclusion criteria were excluded. Initially a total of 108 studies were found, with ten being excluded during title and abstract screening. After scanning 98 papers, a total of 31 RCTs were selected and analyzed. In the 31 RCTs patients with acne were randomized into groups for treatment and control. Specifically the treatment group received fire needling, while the control group were concurrently given other treatments. The results of the completed studies have shown that the treatment group receiving fire needling demonstrated significant improvement compared to the control group.

Conclusion:

During our study it was verified that the efficacy of fire needling for the treatment of acne vulgaris was both significant and meaningful. Therefore, fire needling can be a safe and effective alternative treatment for acne. However, to confirm this result, further investigation in a traditional clinic is required accompanied by high quality studies including randomized, placebo-controlled double-blind trials.

Fig. 1

Flow chart of the trial selection process

A total of 108 studies were found, with ten being excluded during title and abstract screening. After scanning 98 papers, a total of 31 RCTs were selected and analyzed.

RCTs of Fire needling for Acne

RCTs of Fire needling with Traditional Korean Medicine for Acne compared to Western Medicine

RCTs of Fire needling with Traditional Korean Medicine for Acne compared to Traditional Korean Medicine without Fire needling

RCTs of Fire needling with Traditional Korean Medicine for Acne compared to Integrated Medicine Therapy

RCTs of Fire needling with Integrated Medicine Therapy for Acne

References

1. Korean Dermatological Association Textbook Compilation Committee. Textbook of Dermatology 6th edth ed. Seoul: Daehaneuihak; 2014. p. 528–35.
2. Textbook Compilation Committee of Traditional Korean Dermatology and Surgery. Textbook of Traditional Korean Dermatology and Surgery Busan: Seonu; 2007. p. 486–7.
3. Sun SM. The Prescriptions Worth a Thousand Gold for Emergencies Seoul: Dashengmunhuashe; 1992. p. 683.
4. Textbook Compilation Committee of Traditional Korean Acupuncture and Moxibustion Medicine. Textbook of Traditional Korean Acupuncture and Moxibustion Medicine Seoul: Jimmundang; 2014. p. 144–6.
5. Lee JS, Ryu CG, Jeong SS, Moon SI. Review of Fire Needling on Frozen Shoulder: Focusing on Chinese Journals. The Acupuncture 2013;30(3):87–99.
6. Park MK, Kang IA, Shin MG, et al. The Effect of Burning Acupuncture Therapy on the External Epicondylitis: Report of Six Cases. The Acupuncture 2012;29(4):113–21.
7. Lee CH, Park MK, Kang IA, et al. A Case Study of 2 Trigger Finger Patients using Burning Acupuncture Therapy. The Acupuncture 2011;28(6):169–75.
8. World Health Organization. WHO International Standard Terminologies on Traditional Medicine in the Western Pacific Region Geneva: World Health Organization; 2007. p. 243.
9. Ren JX, Huang L, Gao GZ. Chinese-English Dictionary of Traditional Chinese Medicine Beijing: People’s Medical Publishing House; 1997. p. 217.
10. Li Y, He L, Liu BH, Zhang HR, Zhang P, Ai MM. Fire Needle Therapy Combined with Yahnhuotang in the Treatment of Acne of Yang Deficiency Type. J Clin Acup 2011;27(4):11–3.
11. Liu J, Shen BX, Zhang LL, Guan XH, Mai AF, Huang LJ. Study on Therapy Effect of Fire Needling Combined with Red and Blue Equipment Treatment on Acne. J Rare Uncommon Dis 2015;22(4):45–7.
12. Jiang M, Zeng XY, Wang WZ, et al. Efficacy Observation on Fire Needling Therapy for Moderate to Severe Acne Vulgaris. Chin Acup Moxi 2014;34(7):663–6.
13. Jiang M, Jiang K, Zeng XY, Wang WZ. Observations on the Efficacy of Fire Needling Plus Medication in Treating Cystic Acne. Shanghai J Acup Moxi 2015;34(11):1082–4.
14. Wang LN, Qian F, Yang YF, Ma XM. Effect of Cauterized Needling Therapy Combined with Chinese Medicine on IL-2 in Peripheral Blood of Cystic Acne Patients. Hubei J TCM 2014;36(7):13–4.
15. Fan Y. Clinical Efficacy of Fire Needle Treatment of Acne. China Practical Medicine 2016;11(3):275–6.
16. Li GH, She XY, Peng XJ, et al. Fire Acupuncture and Cupping Treatment of Acne Vulgaris Clinical Efficacy. J Sichuan TCM 2015;33(1):156–7.
17. Chen GS, Wei N, Di XX, et al. Photosynthetic and Morus Alba Mask, Fire Needle Treatment Phlegm Stasis Type of Acne 57 Cases. J Fujian TCM 2015;46(3):30–1.
18. Wang GF, Zhang CY, Cui H, et al. Efficacy Observation of Acupuncture Combined with Chinese Medicine Treatment for 31 Cases of Acne (Heat Accumulation Pattern). J Beijing TCM 2015;34(8):659–60.
19. Lim SM, Shin ES, Lee SH, Seo KH, Jung YM, Jang JE. Tools for Assessing Quality and Risk of Bias by Levels of Evidence. J Korean Med Assoc 2011;54(4):419–29.
20. Deng LJ, Ma XW, Lun ZJ, et al. Clinical Research on Treating Acne by Fire Acupuncture Plus Moxibustion for Acne of Yang Deficiency Type. Clin J Chin Med 2014;6(4):51–2.
21. Yang SQ, Wang YY. Clinical evaluation about Eriobotrya Japonica Qingfeiyin and Fire Needle Therapy for Acne Vulgaris Combined with Lungby Wind-Heat Type. Acta Chin Med Pharmacol 2015;43(1):115–6.
22. Cui MH. Clinical Observation of Detoxification Drink Combined with Fire Needle Therapy Toxic Heat Stasis. J Guangxi TCM 2014;37(5):55–6.
23. Wang W, Li JL, Song ZJ, et al. Clinical Observation of Fire Needle Treatment Acne of Teenagers Ages Between 12 and 18. Prenatal Post Care Chin 2014;20(3):196–7.
24. Yang X. Clinical Efficacy on Xiaocuotang Combined with Fire Needle for Cystic Acne. J Guangming TCM 2015;30(11):2347–8.
25. Chen JY. Pingcuotang with Fire Needle Treatment for Acne Vulgaris. Strait Pharmaceutical J 2013;25(11):124–5.
26. Zheng XM. “Micro Fire Needle” with the Backing of Local Prick Acupoint and Cupping Treatment for Acne 330 Cases. J Shanxi TCM 2010;31(6):727–8.
27. Huang S, Zhang Y, Chen CT, Tang Y, Chen Z. Clinical Studies of Fire Needle Treatment for Nodular Cystic Acne: 128 Cases Report. J Chengdu TCM Univ 2004;24(4):13–5.
28. Jiang YQ. TCM Syndrome with Fire Needle Treatment of Acne Clinical Efficacy of 168 Cases. Asia-Pacific Tradi Med 2014;10(22):43–4.
29. Wu HY, Wang JX, Tang B, et al. Efficacy Observation of Fire Needle Combined with Herbal Mask and Blue Light Red for Nodular Cystic Acne. Chin J Aesthetic Med 2015;24(5):76–7.
30. Li WN, Lei M, Zhao Y, Zhang XZ. Effect of Comprehensive External Treatment Quality of Life in Patients with Adolescent Acne. Chin J Aesthetic Med 2015;24(11):84–6.
31. Zheng XY. Guidelines of Clinical Research on Chinese New Herbal Medicine Beijing: Chin Med Sci Press; 2002. p. 292–5.
32. Huang WP, Xie Y. Clinical Investigation on the Therapeutic Effect of Acne Which Is Treated by Fire Needles Combined with Traditional Chinese Herbs. Modern Diag Treat 2012;23(10):1642–3.
33. Yang SQ, Liu YY, Wang SS, Wang SY. Combined Fire Acupuncture Clinical Acne application Professor Wang Yuxi Experience Side. J Sichuan TCM 2015;33(9):134–5.
34. Yang SQ, Liu CX. Fire Needle Combined with Traditional Chinese Medicine Treatment of Acne Vulgaris (Phlegm-Dampness Pattern) 60 Cases. J External Therapy TCM 2014;23(1):9–10.
35. Hu ZF, Wang FY. Efficacy Evaluation of Fire Needle Combined with Xiaocuotang for Acne Vulgaris. Modern Diag Treat 2015;26(1):51–2.
36. Chen LG, Liu JW. The Observation of Acupuncture and Western Medicine Treatment of Severe Acne. Practical J Med 2014;30(5):442–4.
37. Tao XF, Ling LL. Clinical Observation of 33 Cases: Acupuncture and Cupping Combined Treatment for Acne (Spleen-Stomach Dampness-Heat Pattern). J Jiangsu TCM 2014;46(1):61–2.
38. Li S, Wang XF. Fire Needle Therapy Combined with Traditional Chinese Medicine for 108 Cases of Cystic Acne. J Sichuan TCM 2015;33(9):139–40.
39. Guo YY, Quan XR, Qin QR, et al. Clinical Observation of Fire Needle Therapy Combined with Clarithromycin for Cystic Acne 65 Cases. J Jiangsu TCM 2011;43(1):63–4.
40. Fu Y, Jiang M, Sun J, et al. Study on Therapy Effect of Fire Needling Combined with Fruit Acid on the Acne. Chin J Aesthetic Med 2014;23(1):63–4.
41. Tian LH, Chen ZY, Wang J, et al. Fire Needle Therapy Combined with He-Ne Laser Irradiation Treatment of Facial Acne Vulgaris 220 Cases of Summary. J Trad Chin Med Pharm 2014;20(1):72–3.
42. Zhang J. Report of85 Cases of Zhongtongan Capsule with Fire Needle Treatment for Nodular Cystic Acne. J Hunan TCM 2015;31(11):85–7.
43. Wu Q. Golden Mirror of the Medical Orthodoxy 6th edth ed. Bejing: People’s Medical Publishing House; 1996. p. 1603.
44. Seong EJ, Jo EH, Park MC. A Clinical Report on the Acne Treatment with AMTS. J Kor Orient Med Ophthalmol Otolaryngol Dermato 2010;23(3):236–46.
45. Kim HY, Hong SH, Park IH, Shin SH, Kwon YM. Twenty-two Case of Acne Treated by Hwangryunhaedok-tang Pharmacopuncture Therapy Combined with Herbal Medicine and Extrusion. TJ Kor Orient Med Ophthalmol Otolaryngol Dermato 2015;28(3):114–25.
46. Wu GQ. The Great Compendium of Acupuncture and Moxibustion Changsha: Yuelu Press; 1993. p. 329.
47. Yeon SH, Lee SB, Kwon OS, et al. The Safety Assessment of Fire Need1ing. Kor J Orient Med 2012;18(3):103–10.

Article information Continued

Fig. 1

Flow chart of the trial selection process

A total of 108 studies were found, with ten being excluded during title and abstract screening. After scanning 98 papers, a total of 31 RCTs were selected and analyzed.

Table 1

RCTs of Fire needling for Acne

First author (year) sample size (A) Interventions group (B) Control group Outcome assesment Results jadad scale
Fan15)* –2016 (A) n=25
(B) n=26
Fire needling
• Once in 5 days × 4 times
•Skin lesions
Tazarotene cream (external use)
+Clindamycin phosphate gel (external use)
ER (A): 96.0 %
(B): 73.1 %
(p<0.05)
2
Jiang12)* –2014 (A) n=30
(B) n=30
Fire needling
• Once in 5 days × 4 times
•Skin lesions
Doxycycline (oral medication)
+Adapalene gel (external use)
ER (A): 69.0 %
(B): 40.0 %
(p<0.05)
3
Wang23)* –2014 (A) n=42
(B) n=38
Fire needling
• Once in 2~3 days × 10 times
•Skin lesions
Acupuncture
•Skin lesions, LI11, LI4, SP10, SP6
ER (A): 92.8 %
(B): 78.9 %
(p<0.05)
1
Huang27) –2004 (A) n=71
(B) n=57
Fire needling
• Once a week × 4 times
•Skin lesions
0.025 % Tretinoin cream ER (A: 95.8 %
(B): 73.7 %
(p<0.01)
1
*

The baseline characteristics are similar (p>0.05)

ER: The clinical effective rate.

Table 2

RCTs of Fire needling with Traditional Korean Medicine for Acne compared to Western Medicine

First author (year) sample size (A) Interventions group (B) Control group Outcome assesment Results jadad scale
Yang24) -2015 (A) n=23
(B) n=23
Fire needling
•Twice a week × 8 times
•Skin lesions
+Xiaocuotangjiajian
Isotretinoin soft capsules (oral medication) ER (A): 87.0 %
(B): 69.6 %
(p<0.05)
1
Zhang42)* -2015 (A) n=85
(B) n=85
Fire needling
•Unrecorded for 4 weeks
•Skin lesions
+Zhongtongan Capsule
Roxithromycin (oral medication)
+Clindamycin phosphate gel (external use)
ER (A): 78.8 %
(B): 51.8 %
(p<0.05)
1
Wang18)* -2015 (A) n=31
(B) n=31
Fire needling
•Unrecorded for 2 months
•Skin lesions
+Acupuncture
(LI20, SI18, CV24, Ex-HN3, LI4, LI11, SP10, ST44, SP9, ST36)
+Moving cup manipulation
+Qingrechushitang
Minocycline hydrochloride (oral medication)(br)+Clindamycin phosphate (external use) ER (A): 90.32 %
(B): 58.06 %
(p<0.01)
2
Wang14)* -2014 (A) n=75
(B) n=75
Fire needling
•Twice a week×4 times
•Skin lesions BL13,BL17, BL20, BL21, BL25
+Mahuangfuzixixintangjiajian
Minocycline hydrochloride (oral medication) 1) ER
2) IL-2
1) (A): 85.33 %
(B): 53.33 %
(p<0.05)
2) (A): 7.21 ± 4.22
(B): 10.19 ± 3.41
(p<0.05)
2
Chen36)* -2014 (A) n=35
(B) n=35
Fire needling
•Twice a week × 8 times
•Skin lesions
+Acupuncture
+Plum-blossom needle and cupping therapy
(GV14, BL13, BL15, BL17, BL21, BL23)
Isotretinoin (oral medication) ER (A): 85.71
(B): 65.71
(p<0.05)
1
Mild group
(A) n=35
(B) Control1: n=35
Control2: n=35
Control 1)
Acupuncture
•LI4, LI11, ST44, GB14, ST2
Mild group
(A): 97.1 %
(B) Control1: 88.6 %, Control2: 82.9 %
(p<0.05)
Zheng26) -2010 Moderate group
(A) n=40
(B) Control1: n=40
Control2: n=40
Fire needling
•Once in 3~7 days for 8 times
•Skin lesions
+Blood-pricking therapy and cupping (BL13, BL15, BL18, BL20, BL23, BL25)
Control 2)
Metacycline (oral medication)
+Hydrochloride clindamycin phosphate gel (external use)
ER Moderate group
(A): 95.0 %
(B) Control1: 87.5 %
Control2: 77.5 %
(p<0.05)
1
Severe group
(A) n=35
(B) Control1: n=35
Control2: n=35
Severe group
(A): 91.6 %
(B) Control1: 85.7 %, Control2: 77.1 %
(p<0.05)
*

The baseline characteristics are similar (p>0.05)

ER: The clinical effective rate.

IL-2: Serum interleukin-2 Levels

Table 3

RCTs of Fire needling with Traditional Korean Medicine for Acne compared to Traditional Korean Medicine without Fire needling

First author (year) sample size (A) Interventions group (B) Control group Outcome assesment Results jadad scale
Yang33)* -2015 (A) n=34
(B) n=33
Fire needling
• Once or twice a week × 4 times
•Skin lesions
+Pingcuofangjiajian
Xiaocuowan ER (A): 79.41 %
(B): 42.42 %
(p<0.05)
1
Li16)* -2015 (A) n=32
(B) n=30
Fire needling
•Twice a week × 20 times
•Skin lesions
+Cupping therapy
•Skin lesions
Acupuncture
•GV14 Bl13 BL21 BL17 (selection of points according to syndrome)
1) ER
2) Acne-QoL
1) (A): 71.88 %
(B): 66.67 %
(p<0.05)
2) •Self-perception:
(A): 25.59 ± 5.30 (B): 22.69 ± 4.63 (p<0.01)
• Role-emotional:
(A): 26.24 ± 4.13 (B): 21.69 ± 7.13 (p<0.01)
• Role-social:
(A): 18.44 ± 2.13 (B): 17.32 ± 3.21 (p<0.05)
2
Yang21) -2015 (A) n=45
(B) n=44
Fire needling
• Once a week × 6 times
•Skin lesions
+Pipaqingfeiyinjiajian
Pipaqingfeiyinjiajian ER (A): 93.3 %
(B): 70.5 %
(p<0.05)
0
Jiang28)* -2014 (A) n=84
(B) n=84
Fire needling
•Once a week × 3 times
•Skin lesions, BL13, BL15, BL18, BL20, BL23, CV6, CV4
+Herbal medicine after differentiation of syndrome
Herbal medicine after differentiation of syndrome ER (A): 97.6 %
(B): 90.5 %
(p<0.05)
1
Deng20)* -2014 (A) n=30
(B) Control1: n=30
Control2: n=30
Fire needling
•Once a week × 8 times
•Skin lesions
+Moxibustion on Aconiti Lateralis Preparata Radix cake (ST36, CV4, CV6)
Control 1) Fire needling
•Same as (A)
Control 2)
Moxibustion
•Same as (A)
ER (A: 90.00 %
(B) Control 1: 73.33 %, Control 2: 70.00 %
(p<0.05: (A) and Control 1)
(p<0.05: (A) and Control 2)
1
Yang34)* -2014 (A) n=60
(B) n=60
Fire needling
• Twice a week × 4 times
•Skin lesions
+Xiaocuosanjietang
Xiaocuosanjietang ER (A: 80.0 %
(B): 55.0 %
(p<0.05)
1
Li10)* -2011 (A) n=23
(B) n=22
Fire needling
•Once a week × 8 times
•Skin lesions, BL13, BL15, BL18, BL20, BL23, CV12, ST25, CV6, CV4
+Yahnhuotangjiajian
Yahnhuotangjiajian ER (A): 95.65 %
(B): 72.73 %
(p<0.05)
2
Zheng26) -2010 Mild group
(A) n=35
(B) Control1: n=35
Control2: n=35
Fire needling
•Once in 3~7 days for 8 weeks
•Skin lesions
+Blood-pricking therapy and cupping (BL13, BL15, BL18, BL20, BL23, BL25)
Control 1)
Acupuncture
•LI4, LI11, ST44, GB14, ST2
ER Mild group
(A): 97.1 %
(B) Control1: 88.6 %, Control2: 82.9 %
(p<0.05)
1
Moderate group
(A) n=40
(B) Control1: n=40
Control2: n=40
Moderate group
(A): 95.0 %
(B) Control1: 87.5 %, Control2: 77.5 %
(p<0.05)
Severe group
(A) n=35
(B) Control1: n=35
Control2: n=35
Control 2)
Metacycline (oral medication)
+Hydrochloride clindamycin phosphate gel (external use)
Severe group
(A): 91.6 %
(B) Control1: 85.7 %, Control2: 77.1 %
(p<0.05)
*

The baseline characteristics are similar (p<0.05).

ER: The clinical effective rate.

Acne-QoL,: The Acne-Specific Quality of Life Questionnaire.

Table 4

RCTs of Fire needling with Traditional Korean Medicine for Acne compared to Integrated Medicine Therapy

First author (year) sample size (A) Interventions group (B) Control group Outcome assesment Results jadad scale
Hu35)* -2015 (A) n=30
(B) n=30
Fire needling
• Every other week × 8 times
•Skin lesions
+Xiaocuotang
Adapalene gel (external use)
+Xiaocuotang
ER (A): 23.3 %
(B): 10.0 %
(p<0.05)
1
Tao37)* -2014 (A) n=33
(B) n=30
Fire needling
• Once in 5 days × 6 times
•Skin lesions
+Moving cup manipulation
+blood-pricking therapy and cupping
Yiqing capsule (oral medication)
+Fusidic acid cream (external use)
ER (A): 100.00 %
(B): 83.33 %
(p<0.05)
1
Huang32)* -2012 (A) n=44
(B) n=44
Fire needling
• Once a week × 4 times
+Sanpixiaocuotangjiajian
Clindamycin phosphate gel (external use)
+Sanpixiaocuotangjiajian
ER (A): 86.83 ± 5.61
(B): 53.48 ± 7.82
(p<0.05)
1
*

The baseline characteristics are similar (p<0.05).

ER: The clinical effective rate.

Table 5

RCTs of Fire needling with Integrated Medicine Therapy for Acne

First author (year) sample size (A) Interventions group (B) Control group Outcome assesment Results jadad scale
Jiang13)* -2015 (A) n=28
(B) n=29
Fire needling
• Once a week × 4 times
•Skin lesions
+Isotretinoin soft capsules (oral medication)
Isotretinoin soft capsules (oral medication) ER (A): 89.3 %
(B): 34.5 %
(p<0.01)
3
•Self-perception:
(A): 3.76 ± 1.88
(B): 2.37 ± 2.24
(p<0.01)
Li30)* -2015 (A) n=32
(B) n=29
Fire needling
• Once a week × 4 times
•Skin lesions
+Blue and red light therapy
+Gypsum chinese medicine mask sheet
Qingrexiaocuotang Change of Acne-QoL before and after interventions • Role-emotional:
(A): 6.27 ± 2.42
(B): 2.19 ± 1.94 (p<0.01)
1
• Role-social:
(A): 5.36 ± 2.12
(B): 3.03 ± 2.58
(p<0.01)
Li38)* -2015 (A) n=58
(B) n=50
Fire needling
•Twice a week × 4 times
•Skin lesions
+Huajianxiaocuoyinjiajian
+Blue and red light therapy
Huajianxiaocuoyinjiajian ER (A): 96.6 %
(B): 72.0 %
(p<0.05)
1
Wu29)* -2015 (A) n=48
(B) n=47
Fire needling
• Once a week
•Skin lesions
+Chinese medicine mask sheet
Blue and red light therapy
Chinese medicine mask sheet
+Blue and red light therapy
1) ER
2) GAGS
1) (A): 95.83 %
(B): 74.47 %
(p<0.05)
2) (A): 4.56 ± 1.71
(B): 29.78 ± 7.72
(p<0.05)
1
Liu11)* -2015 (A) n=30
(B) n=30
Fire needling
• Once a week × 8 times
•Skin lesions
+Blue and red lights therapy
Blue and red light therapy 1) ER
2) GAGS
1) (A): 83.3 %
(B): 50 %
(p<0.05)
2) (A): 2.33 ± 2.11
(B): 9.27 ± 2.03
(p<0.05)
2
Chen17)* -2015 (A) n=57
(B) n=63
Fire needling
• Once a week × 4 times
•Skin lesions
+Blue and red light therapy
+Mori Cortex Radicis mask sheet
+Hospital original herbal medicine Qingfu 2 (oral)
Blue and red light therapy
+Hospital original herbal medicine Qingfu 2 (oral)
ER (A: 86.0 %
(B): 46.0 %
(p<0.05)
2
Cui22)* -2014 (A) n=20
(B) n=20
Fire needling
•Twice a week × 5 times
•Skin lesions
+Qingrejieduyin
+Clindamycin phosphate gel (external use)
Tanshinone capsule
+Clindamycin phosphate gel (external use)
ER (A): 90 %
(B): 50 %
(p<0.01)
1
Fu40)* -2014 (A) n=30
(B) n=30
Fire needling
• Once a week × 8 times
•Skin lesions
+20 % fruit acid
20 % fruit acid ER (A): 83.3 %
(B): 63.3 %
(p<0.05)
1
Tian41)* -2014 (A)
n=220
(B)
n=212
Fire needling
•Twice a week × 8 times
•Skin lesions
+Helium-Neon lasers
Helium-Neon lasers ER (A): 82.7 %
(B): 77.4 %
(p<0.05)
0
Shen25) -2013 (A)
n=100
(B)
n=100
Fire needling
•Twice a week × 8 times
•Skin lesions
+Amikacin sulfate solution (external use)
+Pingcuotang
Pingcuotang ER (A): 97.0 %
(B): 80.0 %
(p<0.01)
1
Guo39)* -2011 (A) n=65
(B) n=60
Fire needling
• Twice a week × 2 times
•Skin lesions
+Clarithromycin (oral medication)
+Clindamycin and Chlorphenamine Maleate topical solution (external use)
Clarithromycin (oral medication)
+Clindamycin and Chlorphenamine Maleate topical solution (external use)
ER (A): 95.38 %
(B): 78.33 %
(p<0.01)
1