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J Acupunct Res > Volume 32(2); 2015 > Article
Lee, Lee, and Kim: The Anti-wrinkle Effects of Cultivated Wild Ginseng Pharmacopuncture※
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This study was aimed to report the anti-wrinkle effects of cultivated wild ginseng pharmacopuncture.


Data were collected from 23 patients who had been treated with cultivated wild ginseng pharmacopuncture for skin wrinkles. Patients were treated twice a week, for a total of 5 times. To observe the effect of the treatment, we measured the width and depth of skin wrinkles with ECOSKIN(portable fluorescent dermal diagnostic equipment). We also conducted a survey with patients to measure total satisfaction and the anti-wrinkle effect using a semantic differential scale. The evaluation was done 2 times, once before the first treatment and once 1 week after the last treatment. The relationship was measured by Wilcoxon signed rank test.


Skin wrinkle mean width decreased significantly from 9.45±6.60 to 5.54±4.78. Depth decreased significantly from 0.68±0.34 to 0.39±0.24 total satisfaction increased significantly from 2.46±0.743 to 4.13±0.51. Anti-wrinkle effect increased significantly from 2.46±0.63 to 3.93±0.593.


These results suggest that cultivated wild ginseng pharmacopuncture may be effective for decreasing wrinkles.


This research was supported by a grant from Daegu Haany University Ky·lin Foundation in 2014

Table 1.
Details of Acupuncture Technique Based on STRICTA17)
  1. Acupuncture rationale
1a) Style of acupuncture Pharmacopuncture
1b) Reasoning for treatment Based on historical context and anatomical information
  2. Needling details
2a-1) Points used(uni/bilateral) Ex-HN3, GB1, ST4, LI20, GB3(bilateral except for Ex-HN3)
2a-2) Numbers of needles inserted 9
2b) Depths of inserstion 1/2 inch
2c) Responses elicited None
2d) Needle stimulation Cultivated wild ginseng pharmacopuncture is inserted 0.05 cc/1 point
2e) Needle retention time none
2f) Needle type 29 G × 1/2 inch syringe, SIR medical, stainless steel disposable needle
  3. Treatment regimen
3a) Number of treatment sessions 5 times
3b) Frequency of treatment Twice a week
  4. Co-interventions
4a) Other interventions None
  5. Practitioner background
5a) Duration of relevant training More than 3 years of experience about acupuncture and moxibustion medicine
5b) Length of clinical experience More than 4 years of experience
  6. Control intervention
6a) Interventions No control intervention
Table 2.
The Anti-wrinkle Effects of Cultivated Wild Ginseng Pharmacopuncture
Skin evenness Before treatment After treatment p-value
Width 9.45±6.60 5.54±4.78* .000
Depth 0.68±0.34 0.39±0.24* .000

The skin evenness is consisted of width and depth. The meaning of width is the average of skin wrinkle’s width.

The meaning of depth is the average of skin wrinkle’s depth. The value was measured by ECOSKIN.

Values are Mean±SD. Using wilcoxon signed rank test.

* p<0.05.

Table 3.
The Survey of the Anti-wrinkle Effect
Item Before treatment After treatment p-value
Total satisfaction 2.46 ± 0.74 4.13 ± 0.51* .000
Anti-wrinkle effect 2.46±0.63 3.93±0.593* .000

We conducted a survey to patients about total satisfaction, anti-wrinkle effect using semantic differential scale. The position marked 1 is labeled ‘very bad’, the 2 position ‘bad’, the 3 position ‘normal’, the 4 position ‘good’, and the 5 position ‘very good’.

Values are Mean±SD. Using wilcoxon signed rank test.

* p<0.05.



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