A Comparative Study of the Effects of  Pharmacopuncture Treatment and Bee Venom Pharmacopuncture Treatment on Peripheral Facial Paralysis

Se Hoon Im; Min Jun Lee; Seung Min Lee; Eun Seok Kim; Seung Hoon Lee; Jung Won Kang; Yong Suk Kim

doi:10.13045/acupunct.2014031

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Im, Lee, Lee, Kim, Lee, Kang, and Kim: A Comparative Study of the Effects of Jungsongouhyul Pharmacopuncture Treatment and Bee Venom Pharmacopuncture Treatment on Peripheral Facial Paralysis

Clinical Research

The Acupuncture 2014; 31(2): 135-144.

Published online: June 20, 2014

DOI: https://doi.org/10.13045/acupunct.2014031

A Comparative Study of the Effects of Jungsongouhyul Pharmacopuncture Treatment and Bee Venom Pharmacopuncture Treatment on Peripheral Facial Paralysis

Se Hoon Im, Min Jun Lee, Seung Min Lee, Eun Seok Kim, Seung Hoon Lee, Jung Won Kang, Yong Suk Kim^*

Department of Acupuncture & Moxibustion Medicine, College of Korean Medicine, Kyung Hee University

^*Corresponding author : Department of Acupuncture & Moxibustion Medicine, Kangnam Korean Hospital Kyung Hee University, 225, Yeongdong-daero, Gangnam-gu, Seoul, 135-501, Republic of Korea, Tel : +82-2-3457-9014 E-mail : ackys@hanmail.net

Received February 11, 2014 Revised May 09, 2014 Accepted May 21, 2014

This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Abstract

Objectives:

This study was designed to compare the effects of Jungsongouhyul pharmacopuncture treatment with bee venom pharmacopuncture treatment in hospitalized patients with peripheral facial paralysis

Methods:

This study was done on a total of 41 patients with peripheral facial paralysis who were admitted into the Korean Medicine Hospital from February 1st, 2013 to April 30th, 2014. Wedivided patients into two groups. The Jungsongouhyul group was treated by Jungsongouhyul pharmacopuncture once a day and the bee venom group was treated by bee venom pharmacopuncture once a day. To compare the therapeutical effects of the two treatments, we used Yanagihara’s unweighted grading system, House-Brachmann grading system, lip-length & snout indices and facial disablity index twice - before initial treatment and after final treatment.

Results:

Both Yanagihara’s score and House-Brachmann grading system score improved in each group. However, there were no significant differences in improvement between the bee venom group and the Jungsongouhyul group.

Conclusions:

Jungsongouhyul pharmacopuncture treatment appears to be as effective as bee venom pharmacopuncture treatment to improve symptoms of peripheral facial paralysis.

Key Words: PPeripheral facial paralysis; Jungsongouhyul pharmacopuncture; Bee venom pharmacopuncture.

Table 1.

Y-System


At rest	1	2	3	4
Wrinkle forehead	1	2	3	4
Blink	1	2	3	4
Closure of eye tightly	1	2	3	4
Closure of eye lightly	1	2	3	4
Closure of eye on involved side only	1	2	3	4
Wrinkle nose	1	2	3	4
Whistle	1	2	3	4
Grin	1	2	3	4
Depress lower lip	1	2	3	4

Table 2.

H-B Grade

Grade	Description	Characteristics
I	Normal	Normal facial function all areas

II	Mild dysfunction	Gross : Slight weakness noticeable on close inspection may have very slight synkinesis
		At rest : Normal symmetry and tone
		Motion
		Forehead : Moderate to good function
		Eye : complete closure with minimum effort
		Mouth : Slight asymmetry

III	Moderate dysfunction	Gross : obvious but not disfiguring difference between two sides, noticeable but not severe synkinesis, contracture, and/or hemifacial spasm
		At rest : normal symmetry and tone
		Motion
		Forehead : slight to moderate movement
		Eye : complete closure with effort
		Mouth : slightly weak with maximum effort

IV	Moderately severe dysfunction	Gross : obvious weakness and/or disfiguring asymmetry
		At rest : normal symmetry and tone
		Motion
		Forehead : none
		Eye : incomplete closure
		Mouth : asymmetric with maximum effort

V	Severe dysfunction	Gross : only barely perceptible
		At rest : asymmetry
		Motion
		Forehead : none
		Eye : incomplete closure
		Mouth : slight movement

VI	Total paralysis	No movement

Table 3.

General Characteristics

	Jungsongouhyul group(n=21)	BV group(n=20)	p-value
Sex(male/female)	21(9/12)	20(10/10)
Age	41.95±13.13(23∼69)	47.10±12.07(15∼65)	0.137^*
Left/right	11/10	8/12
Period of onset to first hospital visit	7.43±5.36(2∼21)	10.80±6.92(1∼30)	0.105^*
Hospitalization period	11.86±1.65(9∼15)	12.05±1.82(8∼14)	0.560^*
Past history of facial palsy	5	1	0.184^**
Steroid intake	13	16	0.306^**
DM	4	2	0.663^**

BV : bee venom.

DM : diabetes mellitus.

^* calculated by Mann-Whitney U test, p >0.05.

^** calculated by Fisher’s exact test, p >0.05.

Table 4.

The Changes of Scale Score between before Treatment and after Final Treatment in Jungsongouhyul Group

	Before treatment	After treatment	p-value
Y-score	11.52±3.86	19.28±7.46	0.001^*
H-B grade	3.57±0.51	2.81±0.75	0.001
Lip-length	14.66±6.71	22.10±7.63	0.001^*
Snout	17.96±5.59	23.09±5.74	0.001^*
FDI	126.24±27.65	159.95±19.79	0.001^*

Y-score : Yanagihara’s score.

H-B grade : House-Brackmann grade.

FDI : facial disablilty index.

^* p-value<0.05 by Wilcoxon’s signed-rank test.

Table 5.

The Changes of Scale Score between before Treatment and after Final Treatment in BV Group

	Before treatment	After treatment	p-value
Y-score	9.35±3.15	15.80±6.03	0.001^*
H-B grade	3.85±0.59	3.20±0.70	0.001^*
Lip-length	11.84±6.51	20.10±9.82	0.001^*
Snout	15.34±4.37	19.64±4.50	0.001^*
FDI	127.65±27.61	152.90±20.12	0.001^*

Y-score : Yanagihara’s score.

H-B grade : House-Brackmann grade.

FDI : facial disablilty index.

^* p-value<0.05 by Wilcoxon’s signed-rank test.

Table 6.

Comparison of Scale Score before Treatment between Jungsongouhyul Group and BV Group

	Jungsongouhyul group	BV group	p-value
Y-B	11.52±3.86	9.35±3.15	0.053^*
HB-B	3.57±0.51	3.85±0.59	0.132^*
LL-B	14.66±6.71	11.84±6.51	0.188^*
S-B	17.96±5.59	15.34±4.37	0.230^*
FDI-B	126.24±27.65	127.65±27.61	0.686^*

^* calculated by Mann-Whitney U test, p >0.05.

Y-B : Y-score of before treatment.

HB-B : H-B grade of before treatment.

LL-B : LL of before treatment.

S-B : S of before treatment.

FDI-B : FDI of before treatment.

Table 7.

Comparison of Scale Score after Final Treatment between Jungsongouhyul Group and BV Group

	Jungsongouhyul group	BV group	p-value
Y-A	19.28±7.46	15.80±6.03	0.065^*
HB-A	2.81±0.75	3.20±0.70	0.092^*
LL-A	22.10±7.63	20.10±9.82	0.465^*
S-A	23.09±5.74	19.64±4.50	0.052^*
FDI-A	159.95±19.79	152.90±20.12	0.389^*

^* calculated by Mann-Whitney U test, p >0.05.

Y-A : Y-score of after final treatment.

HB-A : H-B grade of after final treatment.

LL-A : lip-length of after final treatment.

S-A : snout of after final treatment.

FDI-A : FDI of after final treatment.

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